Studies & Data

Warfarin listed in top four for emergency hospitalizations     

Boston, MA - Adverse drug events (ADEs) cause an estimated 100,000 emergency hospitalizations for seniors each year, yet two-thirds involve just a handful of anticoagulants and diabetes medications, according to a study published in the November 24 issue of the New England Journal of Medicine.

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Emergency doctors call for the need for routine surveillance of new oral anticoagulants

Boston, MA - Very little can be done for a patient taking dabigatran (Pradaxa, Boehringer Ingelheim) who suffers a traumatic injury, and this new, potentially catastrophic predicament—less of an issue in the warfarin era—underscores the need for routine surveillance of new oral anticoagulants to include hemorrhagic complications and trauma deaths.

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Ethnic Differences in Patient Perceptions of Atrial Fibrillation and Anticoagulation Therapy

by Gregory Y.H. Lip, Sridhar Kamath, Marian Jafri, Afzal Mohammed, and David Bareford



How Can We Avoid Stroke Crisis in Latin America

Stroke Prevention in Patients with Atrial Fibrillation

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How can we avoid a stroke crisis?

A report outlining a coordinated plan in Europe to reduce the health, social and economic burdens of stroke related to Atrial Fibrillation (AF). Endorsed by 17 medical and patient organisations, including the European Primary Care Cardiovascular Society, with the aim of highlighting to European policy makers the need to achieve earlier diagnosis and better management of AF, with the ultimate goal of reducing the risk of stroke in patients with AF.

Further information


Anticoagulation and the elderly

Results from the EPICA Study (Elderly Patients followed by Italian Centres for Anticoagulation Study). This is the largest study on very old patients anticoagulated with Vitamin K antagonists for the prevention of venous thromboembolism and, for the major part (75%), for the prevention of stroke because affected by Atrial Fibrillation.

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Comprehensive risk reduction in patients with Atrial Fibrillation: emerging diagnostic and therapeutic options

Proposal for new physiology-based AF classification is supported by AFNET and EHRA.

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Innovations in support

Business case studies which bring specialist support into general practice.

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ECG interpretation in Primary Care         

Sleep studies


How Can We Avoid a Stroke Crisis in the Asia-Pacific Region?

Working Group Report: Stroke Prevention in Patients with Atrial Fibrillation

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Final SPAF Backgrounder

Final summary


Apixaban as an alternative to aspirin in patients with AF:

New evidence: Connolly et al (N. Engl. J. Med 2011; 364:806-17) conducted a trial in 5599 patients with AF for whom anticoagulation with a vitamin K antagonist was considered unsuitable.

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Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation: A Meta-Analysis

Robert G. Hart, MD; Oscar Benavente, MD; Ruth McBride, BS; and Lesly A. Pearce, MS



Examples of Successful Pulse Screening

Models of pulse screening initiatives have been incorporated into regional clinical practices across England. These documents provide evidence relating to the implementation, effectiveness, cost and outcomes of using pulse checks to identify cardiac arrhythmias.


The cost of poor treatment of abnormal heart rhythm puts patients lives at risk

Source: Medical News Today

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Efficacy and Safety of Dabigatran Compared With Warfarin at Different Levels of International Normalized Ratio Control for Stroke Prevention in Atrial Fibrillation: An Analysis of the RE-LY Trial

Wallentin L, Yusuf S, Ezekowitz MD, et al., on behalf of the RE-LY Investigators.
Lancet 2010;Aug 27.
Study Question: Does the time in therapeutic range (TTR) affect the efficacy of warfarin relative to dabigatran?
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Stroke Prevention in AF, Avoiding a Stroke Crisis

Action for Stroke Prevention, an alliance of cardiologists, neurologists, family doctors and patient groups, have urged EU policymakers to improve stroke risk assessment and diagnosis of atrial fibrillation before the increasing frequency of strokes becomes "a major public health crisis.’’
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NHS Stroke Improvement Programme: Atrial Fibrillation – Detection and Optimal Therapy in Primary Care

Paper reviewing opportunistic screening of pulse palpitation in patients over 65 years of age.





Heart and Stroke Improvement

Commissioning for Stroke, Prevention in Primary Care -
The Role of Atrial Fibrillation
NHS Improvement




Prototype software currently for evaluation only.

‘The Auricle'  is a new screening device currently being developed by NHS Innovations East which links to the CHADS2” risk calculator.

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Atrial fibrillation—so what? Changing clinical practice

Michelle Bennett, BHF Arrhythmia Nurse Specialist, highlights clinical changes improving the management of Atrial Fibrillation. Published by kind permission from the British Journal of Cardiac Nursing.

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Pulmonary vein isolation by duty-cycled bipolar and unipolar radiofrequency energy with a multielectrode ablation catheter, a study to evaluate the feasibility and safety of a novel multielectrode catheter that delivers duty-cycled bipolar and unipolar radiofrequency (RF) energy.
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Atrial Fibrillation, stroke risk and costs, Department of Health data November 2008.

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